In the 17th edition of the SONATA 17 competition announced by the National Science Center in Krakow, three scientists from the Jagiellonian Centre for Experimental Therapeutics (JCET) were among the winners. Today we present the assumption of the project of Dr. Eng. Marta Pacia, “Multimodal approach for a comprehensive assessment of (dys)functional endothelial phenotype in isolated blood vessels”.
Sodium-glucose co-transports 2 inhibitors (SGLT2-I) are a new generation of drugs for diabetes (including empagliflozin or dapagliflozin), however, their spectrum of action goes far beyond the systemic glucose reduction, and theirs protective effect on the ECs is postulated, both in hyperglycaemic conditions and in inflammatory state of the vasculature. Since the mechanism of action of SGLT2-I remains elusive so far, in this project I propose the development of a unique methodology aimed to uncover alterations of chemical, biological, nanostructural, and functional properties of activated/dysfunctional ECs in isolated blood vessels, which brings us closer to unravelling the mystery of how SGLT2-I actually work on the vascular wall. This first stage of the project includes the application of the developed research methodology to characterize the effect of SGLT2-I on inflammation- or hyperglycemia-activated endothelium, while the second stage includes the application of the developed research methodology to reveal the mechanisms of action of SGLT2-I and to verify the therapeutic efficiency of SGLT2-I to reverse endothelial dysfunction.
Funding period: 3 years Budget: PLN 1,650,782