{"id":1244,"date":"2020-10-05T15:40:46","date_gmt":"2020-10-05T13:40:46","guid":{"rendered":"http:\/\/jcet.eu\/new_en\/?p=1244"},"modified":"2020-10-05T15:40:46","modified_gmt":"2020-10-05T13:40:46","slug":"another-ncn-miniature-for-jcet","status":"publish","type":"post","link":"https:\/\/jcet.eu\/new_en\/2020\/10\/05\/another-ncn-miniature-for-jcet\/","title":{"rendered":"Another NCN MINIATURE for JCET"},"content":{"rendered":"\n<p><strong>The latest results of the MINIATURE competition announced by the <\/strong> <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/www.ncn.gov.pl\/?language=en\" target=\"_blank\">National Science Center<\/a><\/strong> <strong>(NCN) in Krakow have brought success to another scientist from <\/strong> <strong>the Jagiellonian Centre for Experimental Therapeutics (JCET)<\/strong> <strong>. PhD Grzegorz Kwiatkowski will carry out a project: <em>&#8220;<\/em><\/strong><em><strong>Non-invasive MRI assessment of microvascular nitric oxide synthase dysfunctionand permeability in the lung endothelium in a mouse model of a chronic heartfailure<\/strong><\/em><strong><em>&#8220;<\/em>.<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Budget: PLN 49,601<\/li><li>Implementation period: 12 months<\/li><\/ul>\n\n\n\n<p>Endothelial dysfunction is a key\ncharacteristic of several cardiovascular diseases including diabetics,\natherosclerosis and hypertension. In particular, global endothelial status holds\na prognostic value in the development of heart failure. Several reports shown\nendothelial dysfunction developed over the course heart failure including\nimpairment ofnitricoxide synthesis. Moreover, at the advanced stage of heart\nfailure, the endothelial impairment was also observed in the lungs. There is,\nhowever, very little known on a relationship between lung microvascular\nendothelial status and heart failure progression. In particular, it is not\nknown whether the lung endothelium exhibits adaptive or maladaptive mechanisms towards\nheart failure progression. The lung endothelium covers up to 30% of the total\nendothelial surface and as such is potentially an\nimportant treatment target. <\/p>\n\n\n\n<p>Recent developments in the Magnetic Resonance Imaging offer novel, dedicated methods to study microcirculation but have not been yet applied to the lungs. We plan to employed state-of-the-art MRI protocols to characterize changes in the lung endothelium phenotype during the progression of heart failure in a mouse model of this disease. <\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"810\" height=\"450\" src=\"http:\/\/jcet.eu\/new_en\/wp-content\/uploads\/2020\/10\/gk-www.png\" alt=\"\" class=\"wp-image-1245\" srcset=\"https:\/\/jcet.eu\/new_en\/wp-content\/uploads\/2020\/10\/gk-www.png 810w, https:\/\/jcet.eu\/new_en\/wp-content\/uploads\/2020\/10\/gk-www-300x167.png 300w, https:\/\/jcet.eu\/new_en\/wp-content\/uploads\/2020\/10\/gk-www-768x427.png 768w\" sizes=\"auto, (max-width: 810px) 100vw, 810px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>The latest results of the MINIATURE competition announced by the National Science Center (NCN) in Krakow have brought success to another scientist from the Jagiellonian Centre for Experimental Therapeutics (JCET) . PhD Grzegorz Kwiatkowski will carry out a project: &#8220;Non-invasive<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1244","post","type-post","status-publish","format-standard","hentry","category-varia"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Another NCN MINIATURE for JCET &#187; JCET<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jcet.eu\/new_en\/2020\/10\/05\/another-ncn-miniature-for-jcet\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Another NCN MINIATURE for JCET &#187; JCET\" \/>\n<meta property=\"og:description\" content=\"The latest results of the MINIATURE competition announced by the National Science Center (NCN) in Krakow have brought success to another scientist from the Jagiellonian Centre for Experimental Therapeutics (JCET) . PhD Grzegorz Kwiatkowski will carry out a project: &#8220;Non-invasive\" \/>\n<meta property=\"og:url\" content=\"https:\/\/jcet.eu\/new_en\/2020\/10\/05\/another-ncn-miniature-for-jcet\/\" \/>\n<meta property=\"og:site_name\" content=\"JCET\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/jcet.eu\/\" \/>\n<meta property=\"article:published_time\" content=\"2020-10-05T13:40:46+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/jcet.eu\/new_en\/wp-content\/uploads\/2020\/10\/gk-www.png\" \/>\n<meta name=\"author\" content=\"Agnieszka Gudek\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Agnieszka Gudek\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/jcet.eu\/new_en\/2020\/10\/05\/another-ncn-miniature-for-jcet\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/jcet.eu\/new_en\/2020\/10\/05\/another-ncn-miniature-for-jcet\/\"},\"author\":{\"name\":\"Agnieszka Gudek\",\"@id\":\"https:\/\/jcet.eu\/new_en\/#\/schema\/person\/aa0014c9ab5728df0c0977a4c5985ed9\"},\"headline\":\"Another NCN MINIATURE for JCET\",\"datePublished\":\"2020-10-05T13:40:46+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/jcet.eu\/new_en\/2020\/10\/05\/another-ncn-miniature-for-jcet\/\"},\"wordCount\":240,\"publisher\":{\"@id\":\"https:\/\/jcet.eu\/new_en\/#organization\"},\"image\":{\"@id\":\"https:\/\/jcet.eu\/new_en\/2020\/10\/05\/another-ncn-miniature-for-jcet\/#primaryimage\"},\"thumbnailUrl\":\"http:\/\/jcet.eu\/new_en\/wp-content\/uploads\/2020\/10\/gk-www.png\",\"articleSection\":[\"Varia\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/jcet.eu\/new_en\/2020\/10\/05\/another-ncn-miniature-for-jcet\/\",\"url\":\"https:\/\/jcet.eu\/new_en\/2020\/10\/05\/another-ncn-miniature-for-jcet\/\",\"name\":\"Another NCN MINIATURE for JCET &#187; 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