{"id":1470,"date":"2021-12-08T16:03:39","date_gmt":"2021-12-08T15:03:39","guid":{"rendered":"http:\/\/jcet.eu\/new_en\/?p=1470"},"modified":"2021-12-08T16:03:40","modified_gmt":"2021-12-08T15:03:40","slug":"opus-21-ncn-what-do-we-not-know-about-breast-cancer","status":"publish","type":"post","link":"https:\/\/jcet.eu\/new_en\/2021\/12\/08\/opus-21-ncn-what-do-we-not-know-about-breast-cancer\/","title":{"rendered":"OPUS 21 NCN: What do we not know about breast cancer?"},"content":{"rendered":"\n<p><strong>In the last edition of the OPUS competition announced by the National Science Center in Krakow, Dr. Marta Sm\u0119da received funding for research on breast cancer issues. In her project, she will examine<\/strong> <em><strong>Breast cancer metastasis-induced endothe<\/strong><\/em><strong><em>lial-mesenchymal transition alongside ageing; implications for therapy.<\/em><\/strong><\/p>\n\n\n\n<p>Ageing\nresults in progressive vascular dysfunction. The cornerstone mechanism that may\nlay behind age- and\/or cancer-dependent deterioration of endothelial function\nis mesenchymal transformation of endothelial cells (EndMT) that may determine\nthe endothelium status and, thus, the outcome of breast cancer. Progression of\nEndMT and its consequences in ageing remain largely unknown. Both cancer and\nageing alter platelet phenotype. Therefore, although circulating platelets of\nhealthy individuals support endothelium function, age- and\/or cancer-altered\nplatelets may act in the opposite way: drive EndMT and disrupt endothelial\nbarrier<strong>. <\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"810\" height=\"450\" src=\"http:\/\/jcet.eu\/new_en\/wp-content\/uploads\/2021\/12\/MSW-w\u0142a\u015bciwa.png\" alt=\"\" class=\"wp-image-1471\" srcset=\"https:\/\/jcet.eu\/new_en\/wp-content\/uploads\/2021\/12\/MSW-w\u0142a\u015bciwa.png 810w, https:\/\/jcet.eu\/new_en\/wp-content\/uploads\/2021\/12\/MSW-w\u0142a\u015bciwa-300x167.png 300w, https:\/\/jcet.eu\/new_en\/wp-content\/uploads\/2021\/12\/MSW-w\u0142a\u015bciwa-768x427.png 768w\" sizes=\"auto, (max-width: 810px) 100vw, 810px\" \/><\/figure>\n\n\n\n<!--more-->\n\n\n\n<p>The project is based on the assumption that mesenchymal transformation forms the basis for age-related endothelial dysfunction and its advancement determines endothelium status as well as the outcomes of breast cancer. The aim of the project is to investigate mesenchymal transformation in the systemic circulation (aorta), and pulmonary circulation (the lungs) alongside ageing as well as during cancer metastasis. It will be also investigated if age- and cancer-altered platelets can affect EndMT progression and endothelial barrier. Finally, it is also planed to seek candidate proteins released from platelets which can determine this process. <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Budget: PLN  3 045\u00a0370 <\/li><li>Implementation period: 48 months<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>In the last edition of the OPUS competition announced by the National Science Center in Krakow, Dr. Marta Sm\u0119da received funding for research on breast cancer issues. In her project, she will examine Breast cancer metastasis-induced endothelial-mesenchymal transition alongside ageing;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1470","post","type-post","status-publish","format-standard","hentry","category-varia"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>OPUS 21 NCN: What do we not know about breast cancer? &#187; JCET<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jcet.eu\/new_en\/2021\/12\/08\/opus-21-ncn-what-do-we-not-know-about-breast-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"OPUS 21 NCN: What do we not know about breast cancer? &#187; JCET\" \/>\n<meta property=\"og:description\" content=\"In the last edition of the OPUS competition announced by the National Science Center in Krakow, Dr. Marta Sm\u0119da received funding for research on breast cancer issues. 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