{"id":2389,"date":"2024-12-05T13:08:19","date_gmt":"2024-12-05T12:08:19","guid":{"rendered":"http:\/\/jcet.eu\/new_en\/?p=2389"},"modified":"2024-12-05T13:08:20","modified_gmt":"2024-12-05T12:08:20","slug":"opus-27-nsc-perivascular-adipose-tissue-in-the-process-of-adipocyte-browning","status":"publish","type":"post","link":"https:\/\/jcet.eu\/new_en\/2024\/12\/05\/opus-27-nsc-perivascular-adipose-tissue-in-the-process-of-adipocyte-browning\/","title":{"rendered":"OPUS 27 NSC – Perivascular adipose tissue in the process of adipocyte browning"},"content":{"rendered":"\n

This week, the National Science Center in Krakow announced the results of the OPUS 27 competition, and Dr. Krzysztof Czamara was among the awardees. Dr. Czamara will lead a project titled: \u201cHeterogeneity of Perivascular Adipose Tissue in the Browning Process: At the Crossroads of Single-Cell Raman Spectroscopy and the Pathophysiology of Adipocytes.\u201d<\/em><\/strong><\/p>\n\n\n\n

The circulatory system status is closely related to the condition of vascular endothelium. In recent years, perivascular adipose tissue (PVAT)\u2014the fat tissue surrounding the aorta\u2014has gained attention as a key player in cardiovascular and lifestyle-related diseases, with its heterogeneous phenotype associated with pathogenesis. In obesity, disruptions in lipid metabolism lead to increased fat accumulation, inflammation, and a loss of thermogenic function. Inducing a brown phenotype in PVAT adipocytes through the activation of uncoupling protein 1 (UCP1), a protein critical for non-shivering thermogenesis, may help prevent cardiovascular disorders. Thus, PVAT browning is emerging as a promising vasoprotective strategy.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n\n\n\n\n

The project aims to develop and validate a unique single-cell Raman imaging methodology for the rapid analysis of PVAT adipocytes and to investigate the molecular mechanisms behind PVAT heterogeneity and changes in PVAT lipid composition upon high-fat diet exposure and subsequent reversal, using RNA sequencing. The developed methodology will be applied to examine PVAT heterogeneity, assess the effects of high-fat diets on PVAT lipid profiles, and explore pharmacological strategies to induce PVAT adipocyte browning. The project integrates in vitro models and molecular biology techniques with in vivo validation, focusing on the vasoprotective effects of PVAT browning in both physiological conditions and obesity induced by a high-fat diet.<\/p>\n\n\n\n

Res<\/a>u<\/a>lts<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

This week, the National Science Center in Krakow announced the results of the OPUS 27 competition, and Dr. Krzysztof Czamara was among the awardees. Dr. Czamara will lead a project titled: \u201cHeterogeneity of Perivascular Adipose Tissue in the Browning Process:<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2389","post","type-post","status-publish","format-standard","hentry","category-varia"],"acf":[],"yoast_head":"\nOPUS 27 NSC - Perivascular adipose tissue in the process of adipocyte browning » JCET<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jcet.eu\/new_en\/2024\/12\/05\/opus-27-nsc-perivascular-adipose-tissue-in-the-process-of-adipocyte-browning\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"OPUS 27 NSC - Perivascular adipose tissue in the process of adipocyte browning » JCET\" \/>\n<meta property=\"og:description\" content=\"This week, the National Science Center in Krakow announced the results of the OPUS 27 competition, and Dr. Krzysztof Czamara was among the awardees. 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