Agnieszka Kij, Ph.D.

Head of the Laboratory of Analytics and Pharmacokinetics
e-mail: agnieszka.kij@jcet.eu

Agnieszka Kij obtained her PhD in Pharmacology and Pharmacy in 2019 at the Faculty of Pharmacy of the Jagiellonian University Collegium Medicum. She has been working and conducting research studies at the Jagiellonian Centre for Experimental Therapeutics (JCET) since 2012, and from 2019 she has been Head of the Laboratory of Analytics and Pharmacokinetics. Her research is mainly focused on a better understanding of lipid mediator-dependent mechanisms involved in the development of endothelial dysfunction. The changes in biosynthesis of a broad spectrum of lipid mediators are assessed in different murine models of cardiovascular and cancer disease by application of ultra-performance liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). In 2015 she received her first research project (Preludium-9) founded by the National Science Centre, and now she is a PI of the project Sonata-17 “In the search of specific oxylipin fingerprint reflecting the development of endothelial dysfunction with the use of non-targeted and targeted lipidomics” carried out in JCET  in the years 2022 to 2025. From 08.2018 to 10.2018 she visited the University of Southern Denmark (SDU, Odense, Denmark), where in the frame of collaboration she conducted studies on the role of eicosanoids in hypertension. From 07.2022 to 10.2022 she completed her internship in the Lipid Mediator Unit (the Queen Mary University of London, William Harvey Institute) broadening the knowledge and experience in the field of lipidomics.

Selected recent publications

  • Kij , Kus K., Czyzynska-Cichon I., Chlopicki S., & Walczak M. (2020). Development and validation of a rapid, specific and sensitive LC-MS/MS bioanalytical method for eicosanoid quantification – assessment of arachidonic acid metabolic pathway activity in hypertensive rats. Biochimie, (171-172), 223-232. doi: 10.1016/j.biochi.2020.03.010
  • Kij A., Bar A., Przyborowski K., Proniewski B., Mateuszuk L., Jasztal A., Kieronska-Rudek A., Marczyk B., Matyjaszczyk-Gwarda K., Tworzydlo A., Enggaard C., Hansen P.B.L., Jensen B., Walczak M., Chlopicki S. (2021). Thrombin Inhibition Prevents Endothelial Dysfunction and Reverses 20-HETE Overproduction without Affecting Blood Pressure in Angiotensin II-Induced Hypertension in Mice. International Journal of Molecular Sciences, 22(16), 8664. doi: 10.3390/ijms22168664

More: https://orcid.org/0000-0003-2233-0564