Prof. Stefan Chlopicki, Ph.D., M.D.

Experimental Pharmacology Research Group 
e-mail: stefan.chlopicki@jcet.eu

  • Director of JCET
  • PI in research projects:
    • Pharmacotherapeutic mechanisms, spectroscopic signatures, and nanomechanics of dysfunctional endothelium in liver steatosis and heart failure; towards organ-specyfic mechanisms
    • Prostacyclin, nitric oxide and carbon monoxide-based pharmacotherapy of endothelial dysfunction and platelet activation-a novel strategy to inhibit cancer metastasis
    • Studies on antiplatelet and antithrombotic activity of CO-relasing molecules (CO-RM)
    • Vascular endothelium in life-style diseases: from basic research to the offer of an innovative endothelium-targeted therapeutic

Major research interest and scientific activity

Experimental pharmacology, pathophysiology and pharmacotherapy of endothelial dysfunction in various diseases, biochemistry of endothelium, pharmacology of inflammation and platelets. Supervisor of 14 PhD thesis. The author and co-author of 234 publications (171 original papers, 27 reviews, 25 editorials, 11 book chapters) and over 200 published abstracts presented at international conferences, His papers were cited by other researchers 1572 times (Web of Science) his h-index is 20 (Web of Science). He has given over 120 invited lectures (at national and international scientific meetings or universities), and organized 10 international or national conferences dedicated to endothelial/vascular pharmacology.

Selected publications

  1. Maslak E, Zabielski P, Kochan K, Kus K, Jasztal A, Sitek B, Proniewski B, Wojcik T, Gula K, Kij A, Walczak M, Baranska M, Chabowski A, Holland RJ, Saavedra JE, Keefer LK, Chlopicki S. The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet. Biochem Pharmacol 2015 Feb 1;93(3):389-400 (IF: 4.77)
  2. Kus K, Walczak M, Maslak E, Zakrzewska A, Gonciarz-Dytman A, Zabielski P, Sitek B, Wandzel K, Kij A, Chabowski A, Holland RJ, Saavedra JE, Keefer LK, Chlopicki S.Hepatoselective Nitric Oxide (NO) Donors, V-PYRRO/NO and V-PROLI/NO, in Nonalcoholic Fatty Liver Disease: A Comparison of Antisteatotic Effects with the Biotransformation and Pharmacokinetics. Drug Metab Dispos 2015 Jul;43(7):1028-36. (IF: 3.3)
  3. Wojcik T, Buczek E, Majzner K, Kolodziejczyk A, Miszczyk J, Kaczara P, Kwiatek W, Baranska M, Szymonski M, Chlopicki S. Comparative endothelial profiling of doxorubicin and daunorubicin in cultured endothelial cells. Toxicol In Vitro 2015 Apr;29(3):512-21. (IF: 3,15)
  4. Kaczara P, Motterlini R, Rosen GM, Augustynek B, Bednarczyk P, Szewczyk A, Foresti R, Chlopicki S. Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells: A role for mitoBKCa channels. Biochim Biophys Acta 2015. Oct;1847(10):1297-309. (IF: 4.55)

Participation in international projects with particular emphasis on the exploitation of R&D results

In last years involved in ca. 10 projects, in particular as a leader in: Vascular endothelium in life-style diseases: from basic research to the offer of an innovative endothelium-targeted therapeutic (Project ID: UDA- POIG.01.01.02-00-069/09), budget: 62 609 375,00 PLN (2009–2015) and Jagiellonian Centre for Experimental Therapeutics (JCET) (Project ID: POIG 02.02.00– 00-014108-03), budget: 45 464 876,00 PLN (2008–2012) and Studies on antiplatelet and antithrombotic activity of CO-releasing molecules (CO-RM) (NCN Project ID: 2013/08/M/NZ7/01034), budget: 1 222 182,00 PLN (2003–2016); Pharmacotherapeutic mechanisms, spectroscopic signatures, and nanomechanics of dysfunctional endothelium in liver steatosis and heart failure; towards organ-specific mechanisms (NCN Project ID: 2015/16/W/NZ4/00070), budget: 6 996 680,00.

Patent applications, patents

The author and co-author of ca. 40 patent applications and patents including e.g. Pat. Appl. UP RP no. P-395074, 31.05.2011 r.; Pat. Appl. USPTO (USA) no. 61/491,543, 31.05.2011 r.; Pat. Appl. WIPO (PCT) no. PCT/IB2012/052691, 30.05.2012 r. and resulting patent applications in selected countries worldwide.

International collaboration: 

prof. U. Mende (Harvard Medical School, BWH, Boston, later: Rhode Island Hospital & Alpert Medical School of Brown University), prof. R.Ventura-Clapier (Univ Paris-Sud, France), prof. B.Podesser (Wien Medical University), prof. Z. Papp (Debrecen University), prof. M.Dambrova (Riga, Latvian Institute of Organic Synthesis), dr. R. Motterlini (University Paris-Est), prof. P. Nachtigal (Charles University in Prague) and others.

 

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